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SPRAVATO® (Esketamine) Therapy

Physician‑Led Treatment for Resistant Depression

Serving Washington, DC • Maryland • Northern Virginia


Depression can persist even in highly capable, high‑functioning individuals.

For adults who have not responded adequately to traditional antidepressants, SPRAVATO® (esketamine) offers an FDA‑approved option for treatment‑resistant depression (TRD) and for depressive symptoms in major depressive disorder with suicidal thoughts or behaviors.

Our practice is a REMS‑certified SPRAVATO® treatment center, providing care in a private, medically supervised setting.

When to Consider SPRAVATO®


You may be a candidate if you:

  • Have tried two or more antidepressants without sufficient improvement

  • Continue to experience persistent depressive symptoms

  • Are seeking an evidence‑based alternative to standard medication strategies

SPRAVATO® is used in combination with an oral antidepressant and integrated into a comprehensive treatment plan.

How It Works


Unlike conventional antidepressants that primarily affect serotonin pathways, SPRAVATO® works on the glutamate system (NMDA receptor modulation), targeting a different mechanism involved in depression.

Some patients experience improvement more rapidly than with traditional medication adjustments.

What to Expect

Treatment is provided in-office:

  • Self-administered nasal spray under physician supervision

  • Monitoring for at least two hours after each session

  • Individualized dosing schedule following FDA protocol

Because temporary sedation or dissociation may occur, transportation home is required after each treatment.

Our Approach

 

We provide:

  • Direct physician oversight

  • Careful medical and psychiatric screening

  • Ongoing medication management

  • Coordination with psychotherapy when appropriate

As a private-pay practice, we maintain a low patient volume to ensure personalized, discreet care.

Documentation for out‑of‑network reimbursement is available upon request.

Schedule a Consultation


If you live in the DC metropolitan area and are exploring options for treatment‑resistant depression, contact our office to arrange a confidential consultation to determine whether SPRAVATO® therapy is appropriate for you.

Treatment room

Venera R. Miller, MD, FAPA, FASAM | Double Board‑Certified Psychiatrist | MD, VA, DC

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